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Consistent with human observations, H2O2 also promoted FOXO4 nuclear translocation in TM3 cells, along with an increase in senescence markers p53, phospho-p53, and p21, while reducing testosterone synthesis-related enzymes like CYP11A1 and CYP17A1

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Future research is needed to validate the initial findings suggesting a link between persistent enteroviral infection and T1D onset by conducting larger, multicenter studies to increase statistical power and overcome the limitations imposed by small sample sizes in current pancreatic tissue and interventional trials, including the DiViD

J Coast Life Med 11:14041420 Maia VS, Berzaghi R, Arruda DC, Machado FC, Loureiro LL, Melo PM, Morais AS, Budu A, Travassos LR (2022) PLP2-derived peptide Rb4 triggers PARP-1-mediated necrotic death in murine melanoma cells

CD226 deletion reduces type 1 diabetes in the NOD mouse by impairing thymocyte development and peripheral T cell activation